Receptor tyrosine kinases positively regulate BACE activity and Amyloid-β production through enhancing BACE internalization

Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1

BACKGROUND Several lines of investigation support the notion that endocytosis is crucial for Alzheimer's disease (AD) pathogenesis. Substantial evidence have already been reported regarding the mechanisms underlying amyloid precursor protein (APP) traffic, but the regulation of beta-site APP-Cleaving Enzyme 1 (BACE-1) distribution among endosomes, TGN and plasma membrane remains unclear. Dynami...

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Giuseppina Tesco,* Young Ho Koh, Eugene L. Kang, Andrew N. Cameron, Shinjita Das, Miguel Sena-Esteves, Mikko Hiltunen, Shao-Hua Yang, Zhenyu Zhong, Yong Shen, James W. Simpkins, and Rudolph E. Tanzi* Genetics and Aging Research Unit Neuroscience Center Massachusetts General Hospital, Charlestown, MA 02129, USA Department of Pharmacology and Neuroscience, University of North Texas Health Science...

CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.

BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction of the β-secretase and α-secretase pathway-mediated processing of APP in the rhesus monkey (nonhuman pr...

Amyloid - , Soluble APP - and - Kinetics during BACE Inhibition

X Justyna A. Dobrowolska,1 Maria S. Michener,5 Guoxin Wu,3 Bruce W. Patterson,2 Robert Chott,2 Vitaliy Ovod,1 Yuriy Pyatkivskyy,1 Kristin R. Wildsmith,1 Tom Kasten,1 Parker Mathers,5 Mandy Dancho,5 Christina Lennox,5 Brad E. Smith,5 David Gilberto,5 Debra McLoughlin,8 Daniel J. Holder,7 Andrew W. Stamford,6 Kevin E. Yarasheski,2 Matthew E. Kennedy,4 Mary J. Savage,3 and Randall J. Bateman1 1Dep...

Phosphorylation of BACE